Hydrochloric Acid → HCID 22633064, compound

HRID 2416640Notes

Reaction equation

HRID 2416640 reaction equation
C(O[N:6]([CH2:9][C:10]([N:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)[CH2:14][CH2:13]1)=[O:11])C=O)(C)(C)C.[ClH:25]>CO.C(OCC)(=O)C>[ClH:24].[ClH:25].[NH2:6][CH2:9][C:10]([N:12]1[CH2:13][CH2:14][N:15]([C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)[CH2:16][CH2:17]1)=[O:11]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86759567HCID 86759567, compound

Product 1

HCID 22633064HCID 22633064, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent2×

Conditions

Temperature
0 °C

Procedure

To a solution of tert-butoxy-N-[2-[4-(4-chlorophenyl)-1-piperazinyl]-2-oxoethyl]formamide (31 g) in methanol (60 ml) was added 4N hydrogen chloride in ethyl acetate (219 ml) at 0° C. and the mixture was stirred at 0° C. for 30 minutes. The reaction mixture was allowed to warm to room temperature, stirred for 1 hour and diluted with ethyl acetate. The resulting solid was collected by filtration and washed with ethyl acetate. The solid was dried to give the title compound (29 g).

Workup

  1. temperatureto warm to room temperature
  2. stirringstirred for 1 hour
  3. filtrationThe resulting solid was collected by filtration
  4. washwashed with ethyl acetate
  5. customThe solid was dried

Sources & evidence

ORD record
ord-b88dc2bd84544e078984f1790b857714
Source dataset
uspto-grants-2004_11
Patent number
US06825200B1

Reaction notes

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