反应详情

温度

0 °C

To a solution of tert-butoxy-N-[2-[4-(4-chlorophenyl)-1-piperazinyl]-2-oxoethyl]formamide (31 g) in methanol (60 ml) was added 4N hydrogen chloride in ethyl acetate (219 ml) at 0° C. and the mixture was stirred at 0° C. for 30 minutes. The reaction mixture was allowed to warm to room temperature, stirred for 1 hour and diluted with ethyl acetate. The resulting solid was collected by filtration and washed with ethyl acetate. The solid was dried to give the title compound (29 g).

1. temperatureto warm to room temperature
2. stirringstirred for 1 hour
3. filtrationThe resulting solid was collected by filtration
4. washwashed with ethyl acetate
5. customThe solid was dried