Hydrochloric Acid → HCID 86759569, compound

HRID 2416646Notes

Reaction equation

HRID 2416646 reaction equation
C(OC([NH:8][C@@H:9]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=1)[C:10]([NH:12][CH2:13][C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])=[O:11])=O)(C)(C)C.[ClH:31]>C(OCC)(=O)C>[ClH:31].[ClH:31].[NH2:8][C@@H:9]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=1)[C:10]([NH:12][CH2:13][C:14]([O:16][CH2:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)=[O:15])=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86759568HCID 86759568, compound

Product 1

HCID 86759569HCID 86759569, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent3×

Procedure

To a solution of benzyl [[(2S)-2-[(tert-butoxycarbonyl)amino]-3-(2-pyridyl)propanoyl]amino]acetate (73.8 g) in ethyl acetate (150 ml) was added dropwise 4N hydrogen chloride in ethyl acetate (669 ml) at 10° C. over 30 minutes. The mixture was warmed to room temperature and stirred for 3 hours. The mixture was diluted with ethyl acetate (300 ml). The resulting precipitate was collected by filtration, washed with ethyl acetate (700 ml), and dried in vacuo to give the title compound.

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with ethyl acetate (700 ml)
  3. customdried in vacuo

Sources & evidence

ORD record
ord-e544bec1c63042e5b2ed2faeca0e6869
Source dataset
uspto-grants-2004_11
Patent number
US06825200B1

Reaction notes

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