反应详情

To a solution of benzyl [[(2S)-2-[(tert-butoxycarbonyl)amino]-3-(2-pyridyl)propanoyl]amino]acetate (73.8 g) in ethyl acetate (150 ml) was added dropwise 4N hydrogen chloride in ethyl acetate (669 ml) at 10° C. over 30 minutes. The mixture was warmed to room temperature and stirred for 3 hours. The mixture was diluted with ethyl acetate (300 ml). The resulting precipitate was collected by filtration, washed with ethyl acetate (700 ml), and dried in vacuo to give the title compound.

1. filtrationThe resulting precipitate was collected by filtration
2. washwashed with ethyl acetate (700 ml)
3. customdried in vacuo