Hydrochloric Acid → HCID 54443000, compound

HRID 2416724Notes

Reaction equation

HRID 2416724 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:29]=[CH:28][C:16]3[CH2:17][C@H:18]([CH2:23][C:24]([O:26]C)=[O:25])[C:19](=[O:22])[NH:20][CH2:21][C:15]=3[CH:14]=2)[CH:3]=1.N1C=CC=CC=1NCCCOC1C=CC2CC(CC(OCC)=O)C(=O)NCC=2C=1.CO.Cl>O>[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:29]=[CH:28][C:16]3[CH2:17][C@H:18]([CH2:23][C:24]([OH:26])=[O:25])[C:19](=[O:22])[NH:20][CH2:21][C:15]=3[CH:14]=2)[CH:3]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 54434818HCID 54434818, compoundHCID 86591931HCID 86591931, compound

Product 1

HCID 54443000HCID 54443000, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

According to the procedure of Example 1(c), except substituting methyl (R)-8-[3-[(4-amino-2-pyridyl)amino]-1-propyloxy]-3-oxo-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetate for the ethyl (±)-8-[3-(2-pyridylamino)-1-propyloxy]-3-oxo-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetate, the title compound was prepared as an off-white solid: [α]D23+74.97° (c 1.45, MeOH); MS (ES) m/e 385.4 (M+H)+. Anal. Calcd for C20H24N4O4. HCl.1.5 H2O: C, 53.63; H, 6.30; N, 12.50. Found: C, 53.87; H, 6.13; N, 12.42.

Sources & evidence

ORD record
ord-7d0d2774c8864096bd075f82d5197d92
Source dataset
uspto-grants-2004_11
Patent number
US06825188B2

Reaction notes

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