反应详情

(R)—N,N-dimethyl-2-(5-(1-methylpyrrolidin-3-ylsulfonyl)-2-neopentyl-1H-benzo[d]imidazol-1-yl)ethanamine (STEP D, 419 mg, 1.03 mmol) was dissolved in ethanol (2 mL). To the resulting solution was added 4 mol/L hydrogen chloride in ethyl acetate solution (502 microL, 2.01 mmol) at room temperature. The whole was concentrated in vacuo. The resulting solid was recrystallized from a mixture of ethanol (5 mL) and ethyl acetate (1.5 mL) to give the title compound (177 mg, 36%).

1. concentrationThe whole was concentrated in vacuo
2. customThe resulting solid was recrystallized from a mixture of ethanol (5 mL) and ethyl acetate (1.5 mL)