Triethylamine → HCID 22632967, compound

HRID 2416786Notes

Reaction equation

HRID 2416786 reaction equation
C(N1C=CN=C1)(N1C=CN=C1)=O.[Cl:13][C:14]1[CH:15]=[C:16]([CH:29]=[CH:30][C:31]=1[F:32])[NH:17][C:18]1[CH:26]=[C:25]([F:27])[C:24]([F:28])=[CH:23][C:19]=1[C:20]([OH:22])=O.Cl.[CH2:34]([O:41][NH2:42])[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1.C(N(CC)CC)C>>[Cl:13][C:14]1[CH:15]=[C:16]([CH:29]=[CH:30][C:31]=1[F:32])[NH:17][C:18]1[CH:26]=[C:25]([F:27])[C:24]([F:28])=[CH:23][C:19]=1[C:20]([NH:42][O:41][CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)=[O:22]

Participants

5

Reactant 4

HCID 8471TriethylamineHCID 682631,1'-CarbonyldiimidazoleHCID 102312Benzyloxyamine hydrochlorideHCID 22632932HCID 22632932, compound

Product 1

HCID 22632967HCID 22632967, compoundYield 104.9%

Procedure

Using General Method 2, the reaction of carbonyldiimidazole (2.60 g, 15.7 mmol), 2-(3-chloro-4-fluoro-anilino)-4,5-difluorobenzoic acid (Example P, 4.32 g, 14.3 mmol), O-benzylhydroxylamine hydrochloride (2.3 g, 14.3 mmol), and triethylamine (2.2 mL, 15.7 mmol) provided 6.1 g of the crude title compound.

Sources & evidence

ORD record
ord-7a504bef88f044c599a64d327e897f78
Source dataset
uspto-grants-2004_11
Patent number
US06825199B2

Reaction notes

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