Triethylamine → HCID 22632940, compound

HRID 2416802Notes

Reaction equation

HRID 2416802 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.C(N(CC)CC)C.[F:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]2[C:31]3[C:26](=[CH:27][C:28]([F:33])=[C:29](F)[CH:30]=3)[C:25](=[O:34])[N:24]([O:35][CH2:36][C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[C:23]2=[O:43])=[CH:18][CH:17]=1>>[F:33][C:28]1[CH:27]=[CH:26][C:31]([N:22]2[C:19]3[C:20](=[CH:21][C:16]([F:15])=[C:17]([N:5]4[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]4)[CH:18]=3)[C:25](=[O:34])[N:24]([O:35][CH2:36][C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=3)[C:23]2=[O:43])=[CH:30][CH:29]=1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 531671-MethylpiperazineHCID 22632885HCID 22632885, compound

Product 1

HCID 22632940HCID 22632940, compoundYield 96.8%

Procedure

Using General Method 4, the reaction of N-methylpiperazine (0.14 mL, 1.23 mmol), triethylamine (0.17 mL, 1.23 mmol), and 1-(4-fluorophenyl)-3-benzyloxy-6,7-difluoro-1H-quinazoline-2,4-dione (Example B-1, 0.163 g, 0.41 mmol) provided 0.19 g of the title compound as a solid.

Sources & evidence

ORD record
ord-260632d221504d8481a9525d92ebfcaf
Source dataset
uspto-grants-2004_11
Patent number
US06825199B2

Reaction notes

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