Triethylamine → HCID 22633026, compound

HRID 2416812Notes

Reaction equation

[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[N:20]1[C:29]2[C:24](=[CH:25][C:26]([F:31])=[C:27](F)[CH:28]=2)[C:23](=[O:32])[N:22]([O:33][CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:21]1=[O:41]>>[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[N:20]1[C:29]2[C:24](=[CH:25][C:26]([F:31])=[C:27]([N:1]3[CH2:5][CH2:4][CH2:3][CH2:2]3)[CH:28]=2)[C:23](=[O:32])[N:22]([O:33][CH2:34][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[C:21]1=[O:41]

Participants

Reactant 3

HCID 8471Triethylamine

HCID 31268Pyrrolidine

HCID 22632993HCID 22632993, compound

Product 1

HCID 22633026HCID 22633026, compoundYield 89%

Procedure

Using General Method 4, the reaction of pyrrolidine (0.063 mL, 0.75 mmol), triethylamine (0.106 mL, 0.75 mmol), and 1-(2-fluorophenyl)-3-benzyloxy-6,7-difluoro-1H-quinazoline-2,4-dione (Example F-1, 0.1 g, 0.25 mmol) provided 0.1 g of the title compound as a solid.

Sources & evidence

ORD record: ord-d85cb4db3c0840fbaf63bcb18c6c6bea
Source dataset: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06825199B2

Reaction notes

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