Purine → N9-cyanoethyl purine
반응식
[N:1]1[CH:9]=[C:8]2[C:4]([N:5]=[CH:6][NH:7]2)=[N:3][CH:2]=1.Br[CH2:11][CH2:12][C:13]#[N:14].[H-].[Na+]>>[C:13]([CH2:12][CH2:11][N:5]1[CH:6]=[N:7][C:8]2[C:4]1=[N:3][CH:2]=[N:1][CH:9]=2)#[N:14]참가 물질
4
실험 절차
More specifically, a purine compound is alkylated with 3-bromopropionitrile in the presence of NaH to give N9-cyanoethyl purine intermediate. Reaction of this intermediate with a methyliodo-ester and lithium 2,2,6,6-tetramethylpiperidine affords a mixture of N7-alkylated and N9-alkylated ester-containing products. Reduction of the ester in N9-alkylated product gives another intermediate, which is converted to a desired purine compound of formula (I) by an alkylation reaction or by reacting with a phosphonate in the presence of tert-butoxide. Similarly, reduction of the ester in N7-alkylated product gives a compound, which reacts with a phosphonate to produce an N7-substituted phosphonate-purine.
출처 및 근거
- ORD 기록
- ord-eacc40c9420544a6ae5ba0c5e998e0a1
- 출처 데이터셋
- uspto-grants-2004_11
- 특허 번호
- US06825348B2
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