反应详情

温度

57.5 °C

To a solution of 4.13 g (0.038 mol) of hydroquinone in 80 mL of acetone was added 5.19 g (0.375 mol) of potassium carbonate and 5.0 g (0.038 mol) of 1-bromo-2-butyne. The resulting mixture was heated at 55-60° C. for 8 h and then stirred overnight at room temperature. The reaction mixture was then poured onto ice and extracted with ether. The combined organics were washed with 1N sodium hydroxide solution. The combined aqueous layers were acidified with 1N HCl solution and extracted with dichloromethane. The dichloromethane layers were washed with water and brine, dried over Na2SO4, filtered through Magnesol® and concentrated in vacuo to provide 2.0 g of the phenol as a brown oil.

1. additionThe reaction mixture was then poured onto ice
2. extractionextracted with ether
3. washThe combined organics were washed with 1N sodium hydroxide solution
4. extractionextracted with dichloromethane
5. washThe dichloromethane layers were washed with water and brine
6. dry with materialdried over Na2SO4
7. filtrationfiltered through Magnesol®
8. concentrationconcentrated in vacuo