反应详情

温度

70 °C

4-amino-benzamidine mono HCl salt (17.2 mg, 0.1 mmole) was suspended in acetonitrile (1 mL). The suspension was treated with 4-acetoxy-3-methoxybenzaldehyde (19.0 mg, 0.1 mmole) and indene(11.6 mg, 0.1 mmole). Indium triflate (11.2 mg, 0.02 mmole) was added and the reaction was heated at 70° C. for 48 hours. To the above mixture was added 100 uL of ammonium hydroxide. After stirring at rt overnight, the desired product 6-(4-Hydroxy-3-methoxy-phenyl)-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinoline-2-carboxamidine was purified using reverse phase HPLC. Mass spectrum: 385(M+1).

1. customthe desired product 6-(4-Hydroxy-3-methoxy-phenyl)-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinoline-2-carboxamidine was purified