Isobutylamine → HCID 69892952, compound

HRID 2417400Notes

Reaction equation

HRID 2417400 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]([C:14]1[CH:19]=[C:18]([O:20][CH3:21])[C:17]([OH:22])=[CH:16][C:15]=1[C:23]1[CH:28]=[CH:27][C:26]([C:29]([OH:31])=O)=[CH:25][C:24]=1[O:32][CH3:33])[CH:8]1[CH2:34][C:35]3[C:40]([CH:7]21)=[CH:39][CH:38]=[CH:37][CH:36]=3)(=[NH:3])[NH2:2].F[P-](F)(F)(F)(F)F.N1(O[P+](N(C)C)(N(C)C)N(C)C)C2C=CC=CC=2N=N1.[CH2:68]([NH2:72])[CH:69]([CH3:71])[CH3:70]>CN(C=O)C>[CH2:68]([NH:72][C:29]([C:26]1[CH:27]=[CH:28][C:23]([C:15]2[CH:16]=[C:17]([OH:22])[C:18]([O:20][CH3:21])=[CH:19][C:14]=2[CH:9]2[CH:8]3[CH2:34][C:35]4[C:40]([CH:7]3[C:6]3[C:11](=[CH:12][CH:13]=[C:4]([C:1](=[NH:3])[NH2:2])[CH:5]=3)[NH:10]2)=[CH:39][CH:38]=[CH:37][CH:36]=4)=[C:24]([O:32][CH3:33])[CH:25]=1)=[O:31])[CH:69]([CH3:71])[CH3:70]

Participants

5

Reactant 3

HCID 6558IsobutylamineHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 22633146HCID 22633146, compound

Product 1

HCID 69892952HCID 69892952, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 2′-(2-Carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5′-hydroxy-2,4′-dimethoxy-biphenyl-4-carboxylic acid (10.7 mg, 0.02 mmol), BOP, (0.04 mmol), diidopropylethylamine (10.3 mg, 0.08 mmol) and isobutylamine (4.4 mg, 0.06 mmol) in DMF was allowed to react at room temperature. Example 235 was purified by HPLC. Mass Spectrum: 591 (M+1).

Workup

  1. customto react at room temperature
  2. customExample 235 was purified by HPLC

Sources & evidence

ORD record
ord-64cbb2c405b24c6f8319cf50b1b2c2f8
Source dataset
uspto-grants-2004_11
Patent number
US06825208B2

Reaction notes

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