Hydrochloric Acid → HCID 69817672, compound

HRID 2417413Notes

Reaction equation

HRID 2417413 reaction equation
[NH:1]([C:8]([NH:10][C:11]1[CH:31]=[CH:30][C:14]([CH2:15][C@H:16]2[CH2:20][O:19]C(C)(C)[N:17]2C(OC(C)(C)C)=O)=[CH:13][CH:12]=1)=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:32]>CO.C(OCC)(=O)C>[ClH:32].[NH2:17][C@H:16]([CH2:20][OH:19])[CH2:15][C:14]1[CH:13]=[CH:12][C:11]([NH:10][C:8]([NH:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[O:9])=[CH:31][CH:30]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86591185HCID 86591185, compound

Product 1

HCID 69817672HCID 69817672, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of tert-butyl (S)-4-[4-[(anilinocarbonyl)amino]benzyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate (1.48 g) in methanol (20 ml) was added 4N hydrogen chloride in ethyl acetate (5 ml) at room temperature, and the solution was stirred at the same temperature for 4 hours. The mixture was evaporated in vacuo, and the residue was triturated with diisopropyl ether to give (S)-N-[4-(2-amino-3-hydroxypropyl)phenyl]-N′-phenylurea hydrochloride (660 mg) as a colorless solide.

Workup

  1. customThe mixture was evaporated in vacuo
  2. customthe residue was triturated with diisopropyl ether

Sources & evidence

ORD record
ord-c8837d7d33a84758ab64d7718949e832
Source dataset
uspto-grants-2004_11
Patent number
US06826033B2

Reaction notes

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