Hydrochloric Acid → HCID 69817674, compound

HRID 2417430Notes

Reaction equation

HRID 2417430 reaction equation
[ClH:1].[OH:2][CH2:3][C@@H:4]([NH:22][CH2:23][C@H:24]([OH:33])[CH2:25][O:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:14])=[CH:8][CH:7]=1>CO>[ClH:1].[OH:2][CH2:3][C@@H:4]([NH:22][CH2:23][C@H:24]([OH:33])[CH2:25][O:26][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:14])=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10113837HCID 10113837, compound

Product 1

HCID 69817674HCID 69817674, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 10% hydrogen chloride in methanol was added N-[4-[(2S)-3-hydroxy-2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino)propyl]phenyl]-N′-phenylurea (70 mg) and stirred for 15 minutes. The reaction mixture was concentrated and followed by recrystallization from ethanol to give N-[4-[(2S)-3-hydroxy-2-([(2S)-2-hydroxy-3-phenoxypropyl]amino]propyl]phenyl]-N′-phenylurea hydrochloride (38 mg) as a white powder.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customfollowed by recrystallization from ethanol

Sources & evidence

ORD record
ord-8c893b9eca7e476abcfcfae418edf41d
Source dataset
uspto-grants-2004_11
Patent number
US06826033B2

Reaction notes

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