Trifluoroacetic acid → HCID 69817723, compound

HRID 2417431Notes

Reaction equation

HRID 2417431 reaction equation
C(OC([N:8]([C@H:20]([CH2:43][O:44][Si](C)(C)C)[CH2:21][C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:29]([NH:31][C:32]2[CH:42]=[CH:41][CH:40]=[CH:39][C:33]=2[C:34]([O:36][CH2:37][CH3:38])=[O:35])=[O:30])=[CH:24][CH:23]=1)[CH2:9][C@H:10]([OH:19])[CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=O)(C)(C)C.[F:49][C:50]([F:55])([F:54])[C:51]([OH:53])=[O:52]>ClCCCl>[F:49][C:50]([F:55])([F:54])[C:51]([OH:53])=[O:52].[OH:44][CH2:43][C@@H:20]([NH:8][CH2:9][C@H:10]([OH:19])[CH2:11][O:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[CH2:21][C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:29]([NH:31][C:32]2[CH:42]=[CH:41][CH:40]=[CH:39][C:33]=2[C:34]([O:36][CH2:37][CH3:38])=[O:35])=[O:30])=[CH:24][CH:23]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69818075HCID 69818075, compound

Product 1

HCID 69817723HCID 69817723, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

To a solution of ethyl 2-[[[[4-[(2S)-2-[N-(tert-butoxycarbonyl)-N-((2S)-2-hydroxy-3-phenoxypropyl)amino]-3-[(trimethylsilyl)oxy]propyl]phenyl]amino]carbonyl]amino]-benzoate (10.0 mg) in 1,2-dichloroethane (100 μl) was added trifluoroacetic acid (100 μl) and the solution was stirred at room temperature for 30 minutes. The solvent was removed by evaporation to give ethyl 2-[[[[4-[(2S)-3-hydroxy-2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]propyl]phenyl]amino]-carbonyl]amino]benzoate trifluoroacetate (10.3 mg) as a white foam.

Workup

  1. customThe solvent was removed by evaporation

Sources & evidence

ORD record
ord-697bb55e7b484aa9b79327c2804ec1ad
Source dataset
uspto-grants-2004_11
Patent number
US06826033B2

Reaction notes

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