Hydrochloric Acid → HCID 69817703, compound

HRID 2417443Notes

Reaction equation

HRID 2417443 reaction equation
[OH:1][CH2:2][C@@H:3]([N:20]([CH2:28][C@H:29]([OH:38])[CH2:30][O:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)C(=O)OC(C)(C)C)[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([C:14]2[N:15]([CH3:19])[CH:16]=[CH:17][CH:18]=2)=[O:13])=[CH:7][CH:6]=1.[ClH:39]>C(O)C>[ClH:39].[OH:1][CH2:2][C@@H:3]([NH:20][CH2:28][C@H:29]([OH:38])[CH2:30][O:31][C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([C:14]2[N:15]([CH3:19])[CH:16]=[CH:17][CH:18]=2)=[O:13])=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69818904HCID 69818904, compound

Product 1

HCID 69817703HCID 69817703, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

tert-Butyl N-[(1S)-2-hydroxy-1-[4-[[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino]benzyl]ethyl]-N-[(2S)-2-hydroxy-3-phenoxypropyl]carbamate (158 mg) was dissolved in 4N hydrogen chloride in ethanol (2.0 ml) and the solution was stirred at room temperature for 2 hours. The solvent was removed by evaporation and the residual solid was dried under reduced pressure to give N-[4-[(2S)-3-hydroxy-2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]propyl]phenyl]-1-methyl-1H-pyrrole-2-carboxamide hydrochloride (125 mg) as a pale orange crystalline solid.

Workup

  1. customThe solvent was removed by evaporation
  2. customthe residual solid was dried under reduced pressure

Sources & evidence

ORD record
ord-a07f73262d5347e8bcad37e4e0d4fd37
Source dataset
uspto-grants-2004_11
Patent number
US06826033B2

Reaction notes

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