Triethylamine → HCID 86589873, compound

HRID 2417485Notes

Reaction equation

HRID 2417485 reaction equation
[Br:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][NH:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:4]([N+:16]([O-:18])=[O:17])[CH:3]=1.[Cl:19][C:20]1[CH:28]=[CH:27][C:23]([C:24](Cl)=[O:25])=[CH:22][CH:21]=1.C(N(CC)CC)C>ClCCl>[N+:16]([C:4]1[CH:3]=[C:2]([Br:1])[CH:15]=[CH:14][C:5]=1[CH2:6][N:7]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[C:24](=[O:25])[C:23]1[CH:27]=[CH:28][C:20]([Cl:19])=[CH:21][CH:22]=1)([O-:18])=[O:17]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 85014-Chlorobenzoyl chlorideHCID 86589872HCID 86589872, compound

Product 1

HCID 86589873HCID 86589873, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

4.2 g (13.1 mmol) of ethyl (4-bromo-2-nitrobenzyl)aminoacetate was dissolved in 30 ml of dichloromethane. 2.2 ml (17.7 mmol) of 4-chlorobenzoyl chloride and 2.9 ml (19.6 mmol) of triethylamine were added to the obtained solution, and they were stirred overnight. After the treatment with dichloromethane as the extracting solvent by an ordinary method, the obtained crude product was purified by the silica gel column chromatography to obtain the crude product.

Workup

  1. customwas purified by the silica gel column chromatography

Sources & evidence

ORD record
ord-79e4272904fb47a8b7b47fbf057c8a53
Source dataset
uspto-grants-2004_11
Patent number
US06825191B2

Reaction notes

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