Ethyl 5-Chloropyridine-2-carboxylate → 5-chloropyridin-2-carboxylic Acid Hydrochloride
Reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([O:10]CC)=[O:9])=[N:6][CH:7]=1>Cl>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:10])=[O:9])=[N:6][CH:7]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 70 °C
Procedure
250 mg (1.35 mmol) of ethyl 5-chloropyridin-2-carboxylate was dissolved in 6 N hydrochloric acid, and the obtained solution was stirred at 70° C. for 2 hours. The solvent was evaporated to obtain the crude product.
Workup
- customThe solvent was evaporated
Sources & evidence
- ORD record
- ord-873face2c133466e8e5ea186d25118e3
- Source dataset
- uspto-grants-2004_11
- Patent number
- US06825191B2
Reaction notes
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