Methyl iodide → HCID 22632485, compound

HRID 2417553Notes

Reaction equation

HRID 2417553 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[Cl:8][C:9]1[C:19]2[CH2:18][N:17]([C:20](=[O:28])[C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)[CH2:16][C:15](=[O:29])[N:14]([CH2:30][C:31]3[CH:36]=[CH:35][C:34]([C:37]4[N:38]([CH3:42])[CH2:39][CH2:40][N:41]=4)=[CH:33][CH:32]=3)[C:13]=2[CH:12]=[CH:11][CH:10]=1.[C:43](=O)([O-])[O-].[K+].[K+].CI>C(#N)C>[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].[Cl:8][C:9]1[C:19]2[CH2:18][N:17]([C:20](=[O:28])[C:21]3[CH:22]=[CH:23][C:24]([Cl:27])=[CH:25][CH:26]=3)[CH2:16][C:15](=[O:29])[N:14]([CH2:30][C:31]3[CH:36]=[CH:35][C:34]([C:37]4[N:41]([CH3:43])[CH2:40][CH2:39][N+:38]=4[CH3:42])=[CH:33][CH:32]=3)[C:13]=2[CH:12]=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 22632330HCID 22632330, compound

Product 1

HCID 22632485HCID 22632485, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

12 mg (0.019 mmol) of 6-chloro-4-(4-chlorobenzoyl)-1-[4-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)benzyl]-1,3,4,5-tetrahydrobenzo[e][1,4]-diazepin-2-on trifluoroacetate was dissolved in 5 ml of acetonitrile. 5 mg (0.036 mmol) of potassium carbonate and 0.010 ml of methyl iodide were added to the obtained solution, and they were stirred at room temperature for 4 hours. The solvent was evaporated, and the obtained crude product was treated in the same manner as in step 3 in Example 1 to obtain the title compound.

Workup

  1. customThe solvent was evaporated
  2. customthe obtained crude product
  3. additionwas treated in the same manner as in step 3 in Example 1

Sources & evidence

ORD record
ord-4f6c92c3084946c6944fbc0c8dd7baea
Source dataset
uspto-grants-2004_11
Patent number
US06825191B2

Reaction notes

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