HRID2417929

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID962

Water

H2O

HCID6328

Methyl iodide

CH3I

HCID11430

Potassium Carbonate

CK2O3

结构：CCCc1c2nc(C(=O)OC)cc(NS(=O)(=O)c3ccc(C)cc3)c2cc2c(=O)cc(C(=O)OCC)oc12

HCID13352258

未命名化合物

PRODUCTS

生成物

结构：CCCc1c2nc(C(=O)OC)cc(N(C)S(=O)(=O)c3ccc(C)cc3)c2cc2c(=O)cc(C(=O)OCC)oc12

HCID20233205

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

PROCEDURE

实验过程

The product of step (a) (5.38 g, 0.01 mol) was suspended in N-methyl pyrrolidone (40 ml), and potassium carbonate (1.38 g, 0.01 mol) added, to give on stirring at room temperature for five minutes a deep red solution. Methyl iodide (2 ml) was then added, and the whole warmed to 40° C., and stirring continued for one hour. The solution was poured into water (150 ml), to give the sub-title compound on filtration, as a white powder, 5.44 g, (98.6%), m.p. 173°-174° C.

WORKUP

后处理

customto give
temperaturethe whole warmed to 40° C.
stirringstirring
waitcontinued for one hour

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3fd575d1e3c745b5ad0e0ca56bd35cb4
来源数据集: uspto-grants-1984_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04471119
来源说明: uspto-grants-1984_09

反应 SMILES

[CH3:1][O:2][C:3]([C:5]1[CH:14]=[C:13]([NH:15][S:16]([C:19]2[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=2)(=[O:18])=[O:17])[C:12]2[C:7](=[C:8]([CH2:36][CH2:37][CH3:38])[C:9]3[O:29][C:28]([C:30]([O:32][CH2:33][CH3:34])=[O:31])=[CH:27][C:26](=[O:35])[C:10]=3[CH:11]=2)[N:6]=1)=[O:4].[C:39](=O)([O-])[O-].[K+].[K+].CI.O>CN1CCCC1=O>[CH3:1][O:2][C:3]([C:5]1[CH:14]=[C:13]([N:15]([CH3:39])[S:16]([C:19]2[CH:20]=[CH:21][C:22]([CH3:25])=[CH:23][CH:24]=2)(=[O:18])=[O:17])[C:12]2[C:7](=[C:8]([CH2:36][CH2:37][CH3:38])[C:9]3[O:29][C:28]([C:30]([O:32][CH2:33][CH3:34])=[O:31])=[CH:27][C:26](=[O:35])[C:10]=3[CH:11]=2)[N:6]=1)=[O:4]