Methylamine → HCID 178482511, compound

HRID 2418054Notes

Reaction equation

HRID 2418054 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[S:6][CH:7]=[C:8]([CH2:10]O)[N:9]=1)[CH3:3].Cl.[SH:13][CH2:14][CH2:15][CH2:16][NH2:17].CO[C:20]1[C:24](OC)=[N:23][S:22](=[O:28])(=[O:27])[N:21]=1.[CH3:29][NH2:30]>Br>[CH3:1][N:2]([CH2:4][C:5]1[S:6][CH:7]=[C:8]([CH2:10][S:13][CH2:14][CH2:15][CH2:16][NH:17][C:20]2[C:24]([NH:30][CH3:29])=[N:23][S:22](=[O:28])(=[O:27])[N:21]=2)[N:9]=1)[CH3:3]

Participants

6

Reactant 4

HCID 6329MethylamineHCID 197870(3-Mercaptopropyl)ammonium chlorideHCID 1838020(2-((Dimethylamino)methyl)thiazol-4-yl)methanolHCID 122305383,4-Dimethoxy-1,2,5-thiadiazole 1,1-dioxide

Product 1

HCID 178482511HCID 178482511, compound

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

When 2-dimethylaminomethyl-4-hydroxymethylthiazole [prepared in Example 34, Step D] is reacted with 3-mercaptopropylamine hydrochloride [prepared according to the procedure described in J. Org. Chem., 27, 2846 (1962)] in aqueous hydrobromic acid (48%), and the resultant amine is successively treated with 3,4-dimethoxy-1,2,5-thiadiazole 1,1-dioxide and excess methylamine as in the general procedure of Example 31, the title compound is produced.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-abf504d2b02747e9a183eb2d5c06ec1e
Source dataset
uspto-grants-1984_09
Patent number
US04471122

Reaction notes

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