Acetone → HCID 22827676, compound

HRID 2418189Notes

Reaction equation

HRID 2418189 reaction equation
C([O:5][C:6](=[O:46])[C@H:7]([CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[NH:8][C:9](=[O:38])[CH2:10][N:11]([C:17](=[O:37])[C@H:18]([CH3:36])[NH:19][C@@H:20]([C:29]([O:31][CH2:32][CH2:33][CH2:34][CH3:35])=[O:30])[CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1)(C)(C)C.CC(C)=O.CCOCC.[ClH:56]>C(OCC)(=O)C>[ClH:56].[CH2:32]([O:31][C:29]([C@H:20]([NH:19][C@H:18]([C:17]([N:11]([CH:12]1[CH2:13][CH2:14][CH2:15][CH2:16]1)[CH2:10][C:9]([NH:8][C@H:7]([C:6]([OH:46])=[O:5])[CH2:39][C:40]1[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=1)=[O:38])=[O:37])[CH3:36])[CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:30])[CH2:33][CH2:34][CH3:35]

Participants

6

Reactant 4

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 13385104HCID 13385104, compound

Product 1

HCID 22827676HCID 22827676, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

N-[1(R)-Butoxycarbonyl-3-phenylpropyl]-L-alanyl-N-cyclopentylglycyl-L-phenylalanine tert-butyl ester (1 g) is dissolved in 14 ml of 3.4N hydrogen chloride in ethyl acetate, followed by addition of 2 ml of acetone. Then, 10 ml of ether is added and the solvent is decanted off. The residue is dried under reduced pressure to give 0.8 g of N-[1(R)-butoxycarbonyl-3-phenylpropyl]-L-alanyl-N-cyclopentylglycyl-L-phenylalanine hydrochloride as colorless powder.

Workup

  1. customthe solvent is decanted off
  2. customThe residue is dried under reduced pressure

Sources & evidence

ORD record
ord-869899ae00c14c9dbcdca7744e07e0d0
Source dataset
uspto-grants-1984_09
Patent number
US04472383

Reaction notes

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