Hydrochloric Acid → HCID 88724528, compound

HRID 2418204Notes

Reaction equation

HRID 2418204 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]([C:49]([OH:51])=[O:50])[CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]([C:45](=[O:48])[CH:46]=[O:47])[CH:20]2[CH2:23][N:22]([CH:24]([C:28]3[CH:33]=[CH:32][C:31]([O:34][C:35](=[O:43])[NH:36]C(=O)C(Cl)(Cl)Cl)=[CH:30][CH:29]=3)[C:25]([OH:27])=[O:26])[C:21]2=[O:44])=[CH:15][CH:14]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(=O)(O)[O-].[Na+].CO.Cl>O>[C:1]([O:5][C:6]([NH:8][CH:9]([C:49]([OH:51])=[O:50])[CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]([C:45](=[O:48])[CH:46]=[O:47])[CH:20]2[CH2:23][N:22]([CH:24]([C:28]3[CH:29]=[CH:30][C:31]([O:34][C:35](=[O:43])[NH2:36])=[CH:32][CH:33]=3)[C:25]([OH:27])=[O:26])[C:21]2=[O:44])=[CH:15][CH:14]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 516892Sodium BicarbonateHCID 131711788HCID 131711788, compound

Product 1

HCID 88724528HCID 88724528, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-[3-{4-(3-tert-Butoxycarbonylamino-3-carboxypropoxy)phenylglyoxyloylamino}-2-oxo-1-azetidinyl]-2-[4-{N-(2,2,2-trichloroacetyl)carbamoyloxy}phenyl]acetic acid (550 mg.) was suspended in water (5 ml.), and to the suspension there were added sodium bicarbonate (250 mg.) and methanol (1 ml.). The mixture was stirred at ambient temperature for 7 hours. The reaction mixture was adjusted to pH 2 with dilute hydrochloric acid and the precipitating material was collected by filtration. The material was washed with water and then dried to give 2-[3-{4-(3-tert-butoxycarbonylamino-3-carboxypropoxy)phenylglyoxyloylamino}-2-oxo-1-azetidinyl]-2-(4-carbamoyloxyphenyl)acetic acid.

Workup

  1. filtrationthe precipitating material was collected by filtration
  2. washThe material was washed with water
  3. customdried

Sources & evidence

ORD record
ord-965bf81cac104c1aac14f3de4d4bc6a2
Source dataset
uspto-grants-1984_09
Patent number
US04472300

Reaction notes

Loading…