Methanesulfonic Acid → HCID 20446051, compound

HRID 2418226Notes

Reaction equation

HRID 2418226 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][C:13]([NH:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[O:14])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[CH3:22][S:23]([OH:26])(=[O:25])=[O:24]>C(O)(C)C>[CH3:22][S:23]([OH:26])(=[O:25])=[O:24].[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][C:13]([NH:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[O:14])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 13338827HCID 13338827, compound

Product 1

HCID 20446051HCID 20446051, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Conditions

Temperature
0 °C

Procedure

To a stirred solution of 4.53 g of ethyl N-(((5-chloro-8-quinolinyl)oxy)carbonyl)glycinate (prepared as described in Example 1) in 80 ml of isopropanol was added a solution of 1.56 g methanesulfonic acid in 10 ml of isopropanol. The resulting solution was cooled to about 0° C. to yield a white solid which was isolated and recrystallized from ethanol to give the purified ethyl N-(((5-chloro-8-quinolinyl)oxy)carbonyl)glycinate methanesulfonic acid salt as white fibrous crystals, m.p. 108°-110° C.

Workup

  1. customto yield a white solid which
  2. customwas isolated
  3. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-a6bb2e242d6341f0a991e617624ee02e
Source dataset
uspto-grants-1984_09
Patent number
US04472404

Reaction notes

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