Ammonium Hydroxide → HCID 178422902, compound

HRID 2418231Notes

Reaction equation

HRID 2418231 reaction equation
C(O[CH:4](OCC)[CH2:5][NH:6][C:7]([NH:9][C:10]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:11]=1[CH:12]=[CH:13][C:14]([CH3:20])=[N:15]2)=[S:8])C.[OH-].[NH4+]>Cl>[SH:8][C:7]1[N:9]([C:10]2[CH:19]=[CH:18][CH:17]=[C:16]3[C:11]=2[CH:12]=[CH:13][C:14]([CH3:20])=[N:15]3)[CH:4]=[CH:5][N:6]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 13338834N-(2,2-Diethoxyethyl)-N'-(2-methylquinolin-5-yl)thiourea

Product 1

HCID 178422902HCID 178422902, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
20 °C

Procedure

A mixture of 8.6 g (28 mmole) of N-(2,2-diethoxyethyl)-N'-(2-methylquinolin-5-yl)thiourea and 100 ml of 10% hydrochloric acid was heated on a steam bath for one hour. The solution was allowed to cool to about 20° C., and was then poured with vigorous stirring into a mixture of ice and ammonium hydroxide. The solid was separated by filtration, washed with water, and triturated with ethyl acetate to provide solid 5-(2-mercaptoimidazol-1-yl)-2-methylquinoline.

Workup

  1. temperaturewas heated on a steam bath for one hour
  2. additionwas then poured
  3. customThe solid was separated by filtration
  4. washwashed with water
  5. customtriturated with ethyl acetate

Sources & evidence

ORD record
ord-05018f18c2ca407fbaf8ec5c37b67e3b
Source dataset
uspto-grants-1984_09
Patent number
US04472406

Reaction notes

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