Tetrahydrofuran → Acetanilide

HRID 2418293Notes

Reaction equation

HRID 2418293 reaction equation
C1(C(SC[CH2:10][C:11]([NH:13][CH2:14][C:15](O)=O)=[O:12])=O)SC=CC=1.O1[CH2:22][CH2:21][CH2:20][CH2:19]1.C(OC(Cl)=O)C>C(Cl)Cl>[C:11]([NH:13][C:14]1[CH:15]=[CH:22][CH:21]=[CH:20][CH:19]=1)(=[O:12])[CH3:10]

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 10928Ethyl chloroformateHCID 54151966HCID 54151966, compound

Product 1

HCID 904Acetanilide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5.4 grams (0.020 moles) of 2-thenoylmercaptopropionylglycine were added to 50 ml of tetrahydrofurane. The temperature of the resulting mixture was brought to 0° C., then a solution of ethylchloroformate (2.2 grams; 0.020 moles) in 10 ml of anhydrous CH2Cl2 was slowly added. To the resulting solution, the following solution was slowly added:

Workup

  1. customwas brought to 0° C.
  2. additionTo the resulting solution, the following solution was slowly added

Sources & evidence

ORD record
ord-f00f7553e5424222a6e1c4fcaf05908b
Source dataset
uspto-grants-1984_09
Patent number
US04472424

Reaction notes

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