Water → HCID 54118377, compound

HRID 2418295Notes

Reaction equation

HRID 2418295 reaction equation
[CH3:1][O:2][C:3](=[O:14])[C@H:4]([CH3:13])[NH:5][C:6]1[C:10]([CH3:11])=[CH:9][S:8][C:7]=1[CH3:12].C([O-])([O-])=O.[K+].[K+].O.[C:22](Cl)(=[O:26])[CH:23]=[CH:24][CH3:25]>ClCCl>[CH3:1][O:2][C:3](=[O:14])[C@H:4]([CH3:13])[N:5]([C:22](=[O:26])[CH:23]=[CH:24][CH3:25])[C:6]1[C:10]([CH3:11])=[CH:9][S:8][C:7]=1[CH3:12]

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 790802-Butenoyl chlorideHCID 22827697HCID 22827697, compound

Product 1

HCID 54118377HCID 54118377, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 6.39 g (0.03 mol) of N-(2,4-dimethylthien-3-yl-alanine-methylester, 4.15 g (0.03 mol) of K2CO3, 10 ml of water and 100 ml of dichloromethane are added without cooling 3.14 g (0.03 mol) 2-butenoyl chloride.

Sources & evidence

ORD record
ord-dc1e4e81ad2c41a6aba6eb983deaacf5
Source dataset
uspto-grants-1984_09
Patent number
US04472425

Reaction notes

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