Toluene → HCID 20446128, compound

HRID 2418296Notes

Reaction equation

HRID 2418296 reaction equation
[H-].[Na+].[CH3:3][C:4]1[S:5][CH:6]=[C:7]([CH3:20])[C:8]=1[N:9]([C:15](=[O:19])[CH2:16][O:17][CH3:18])[NH:10][C:11]([O:13][CH3:14])=[O:12].[C:21]1(C)C=CC=CC=1>C(OCC)C>[CH3:3][C:4]1[S:5][CH:6]=[C:7]([CH3:20])[C:8]=1[N:9]([C:15](=[O:19])[CH2:16][O:17][CH3:18])[N:10]([CH3:21])[C:11]([O:13][CH3:14])=[O:12]

Participants

5

Reactant 3

HCID 1140TolueneHCID 24758Sodium hydrideHCID 20446126HCID 20446126, compound

Product 1

HCID 20446128HCID 20446128, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

0.73 g (0.03 mol) NaH and 7.95 (0.03 mol) methyl 2-(2,4-dimethylthien-3-yl)-2-(methoxyacetyl)-hydrazinecarboxylate in 100 ml dry toluene are heated under reflux for 3 hours. The reaction mixture is then, together with 9.52 g (0.067 mol) CH3J, transferred into a sealed cylinder and heated 20 hours at 110°. The mixture is, after cooling, diluted with diethylether, washed with water, dried and evaporated to yield the title compound.

Workup

  1. temperatureunder reflux for 3 hours
  2. temperatureheated 20 hours at 110°
  3. temperatureafter cooling
  4. washwashed with water
  5. customdried
  6. customevaporated

Sources & evidence

ORD record
ord-2b7c1168b1894988858c2a6adb198a27
Source dataset
uspto-grants-1984_09
Patent number
US04472425

Reaction notes

Loading…