反应详情

To the 1-ethylpiperazine (2.33 g, 20.2 mmol) and K2CO3 (2.79 g, 20.2 mmol) in acetone (27 ml) was added propargyl bromide (2.00 g, 13.5 mmol) dropwise at 0° C. under N2. The reaction was stirred at room temperature overnight. The reaction was filtered and the salts washed with a small amount of acetone. The filtrates were combined and evaporated gently to concentration. The residue was taken up in EtOAc and washed with water. The aqueous phase was re-extracted with EtOAc. The combined organic layers were washed with brine and dried over MgSO4. The product was filtered and evaporated to dryness to leave a pale orange oil.

1. filtrationThe reaction was filtered
2. washthe salts washed with a small amount of acetone
3. customevaporated gently to concentration
4. washwashed with water
5. extractionThe aqueous phase was re-extracted with EtOAc
6. washThe combined organic layers were washed with brine
7. dry with materialdried over MgSO4
8. filtrationThe product was filtered
9. customevaporated to dryness
10. customto leave a pale orange oil