Hydrochloric Acid → HCID 131713686, compound

HRID 2418301Notes

Reaction equation

HRID 2418301 reaction equation
[CH3:1][O:2][CH2:3][C:4]([N:6]([C:11]1[C:15]([CH3:16])=[CH:14][S:13][C:12]=1[CH3:17])[CH:7]([CH3:10])[C:8]#[CH:9])=[O:5].[OH-].[Na+].[I:20]I.Cl>CO>[CH3:1][O:2][CH2:3][C:4]([N:6]([C:11]1[C:15]([CH3:16])=[CH:14][S:13][C:12]=1[CH3:17])[CH:7]([CH3:10])[C:8]#[C:9][I:20])=[O:5]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 807IodineHCID 14798Sodium HydroxideHCID 13341209HCID 13341209, compound

Product 1

HCID 131713686HCID 131713686, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2.51 g (0.01 mol) 2-methoxy-N-(2,4-dimethylthien-3-yl)-N-(1-butin-3-yl)-acetamide, 1.3 g (0.0325 mol) NaOH and 100 ml methanol are cooled with stirring to 10°, and 2.65 g (0.01 mol) powdered iodine is then slowly added. The mixture is then stirred for 3 hours at room temperature, neutralized with methanolic HCl-solution, and the solvent evaporated to yield, after chromatography, the title compound.

Workup

  1. temperatureare cooled
  2. additionis then slowly added
  3. stirringThe mixture is then stirred for 3 hours at room temperature
  4. customthe solvent evaporated
  5. customto yield

Sources & evidence

ORD record
ord-d17f9fa342b14a00bfe4ed64ca912c9e
Source dataset
uspto-grants-1984_09
Patent number
US04472425

Reaction notes

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