Water → N-(2,4-Dimethylthiophen-3-yl)-2-methoxyacetamide

HRID 2418303Notes

Reaction equation

HRID 2418303 reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH3:8])[C:6]=1[NH2:7].C([O-])([O-])=O.[K+].[K+].O.[CH3:16][O:17][CH2:18][C:19](Cl)=[O:20]>C(Cl)Cl>[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH3:8])[C:6]=1[NH:7][C:19](=[O:20])[CH2:18][O:17][CH3:16]

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 96623Methoxyacetyl chlorideHCID 133411982,4-Dimethylthiophen-3-amine

Product 1

HCID 13341230N-(2,4-Dimethylthiophen-3-yl)-2-methoxyacetamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 12.7 g (0.1 mol) of 2,4-dimethyl-3-aminothiophene, 13.84 g (0.1 mol) of K2CO3, 50 ml of water and 160 ml of methylene chloride are added without cooling 10.8 g (0.1 mol) of methoxyacetyl chloride.

Sources & evidence

ORD record
ord-043384c35a7241f89787a6dc3bc4aabb
Source dataset
uspto-grants-1984_09
Patent number
US04472425

Reaction notes

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