Potassium Carbonate → HCID 22827697, compound

HRID 2418304Notes

Reaction equation

HRID 2418304 reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH3:8])[C:6]=1[NH2:7].C([O-])([O-])=O.[K+].[K+].Br[CH:16]([CH3:21])[C:17]([O:19][CH3:20])=[O:18]>CN(C)C=O>[CH3:20][O:19][C:17](=[O:18])[C@H:16]([CH3:21])[NH:7][C:6]1[C:5]([CH3:8])=[CH:4][S:3][C:2]=1[CH3:1]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 95576Methyl 2-bromopropionateHCID 133411982,4-Dimethylthiophen-3-amine

Product 1

HCID 22827697HCID 22827697, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 12.7 g (0.1 mol) 2,4-dimethyl-3-aminothiophene, 13.84 g (0.1 mol) K2CO3 and 16.7 g (0.1 mol) methyl 2-bromopropionate in 200 ml dimethylformamide are stirred over night at 80°. The mixture is cooled, filtered, evaporated, the residue dissolved in dichloromethane, washed with water, dried and evaporated to yield the title compound, m.p. 33°-34°.

Workup

  1. temperatureThe mixture is cooled
  2. filtrationfiltered
  3. customevaporated
  4. dissolutionthe residue dissolved in dichloromethane
  5. washwashed with water
  6. customdried
  7. customevaporated

Sources & evidence

ORD record
ord-59ceae5bb34b4ad7812e7f9093883a59
Source dataset
uspto-grants-1984_09
Patent number
US04472425

Reaction notes

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