反应详情

温度

85 °C

A mixture of 2-chlorobenzenethiol (8.0 g.), ethyl 2-(2-nitro-3-chlorophenyl)acetate (12.2 g.), anhydrous potassium carbonate (7.5 g.) and dry dimethylformamide (50 ml.) was stirred for an hour at 85° C. The reaction mixture was poured into water (300 ml.) and extracted with diethyl ether. The extract was washed with a saturated aqueous solution of sodium chloride, dried over magnesium sulfate and evaporated under reduced pressure. The oily residue was pulverized and recrystallized from methanol (20 ml.) to give the captioned compound (11.6 g.). mp 78° to 80° C.

1. extractionextracted with diethyl ether
2. washThe extract was washed with a saturated aqueous solution of sodium chloride
3. dry with materialdried over magnesium sulfate
4. customevaporated under reduced pressure
5. customrecrystallized from methanol (20 ml.)
6. customto give the captioned compound (11.6 g.)