Allyl bromide → HCID 20446372, compound

HRID 2418458Notes

Reaction equation

HRID 2418458 reaction equation
[CH3:1][C:2]1([CH3:18])[CH2:7][CH:6]([N:8]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][C:9]2=[O:15])[CH2:5][C:4]([CH3:17])([CH3:16])[NH:3]1.C(=O)([O-])[O-].[Na+].[Na+].[CH2:25](Br)[CH:26]=[CH2:27]>CN(C)C=O>[CH2:27]([N:3]1[C:4]([CH3:17])([CH3:16])[CH2:5][CH:6]([N:8]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][C:9]2=[O:15])[CH2:7][C:2]1([CH3:18])[CH3:1])[CH:26]=[CH2:25]

Participants

5

Reactant 3

HCID 7841Allyl bromideHCID 10340Sodium CarbonateHCID 185514351-(2,2,6,6-Tetramethylpiperidin-4-yl)azepan-2-one

Product 1

HCID 20446372HCID 20446372, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

Following the general procedure of Example 3, 12.1 g (0.05 mole) of the compound prepared in Example 1 is dissolved in 75 ml of N,N-dimethylformamide containing a suspension of 10.6 g (0.1 mole) of sodium carbonate. To this mixture is then added 14.6 g (0.05 mole) of allyl bromide and the reaction mixture is then heated at 80° C. for two hours. The solvent is then removed in vacuo and the residue is vacuum distilled at 171°-176° C./0.7 mm to give 7.6 g of the above named product.

Workup

  1. customThe solvent is then removed in vacuo
  2. distillationdistilled at 171°-176° C./0.7 mm
  3. customto give 7.6 g of the above named product

Sources & evidence

ORD record
ord-b91a10d47f7542bb87dc3c47f058c968
Source dataset
uspto-grants-1984_09
Patent number
US04472547

Reaction notes

Loading…