Acetic Acid → Ninhydrin

HRID 2418516Notes

Reaction equation

HRID 2418516 reaction equation
[CH2:1]([OH:5])[CH2:2][CH2:3][CH3:4].[C:6]([OH:9])(=[O:8])[CH3:7].[OH2:10].[CH:11](Cl)(Cl)Cl.C(N([CH2:20][CH3:21])CC)C>CO>[CH:21]1[CH:20]=[C:11]2[C:7]([C:6]([OH:9])([OH:8])[C:1](=[O:5])[C:2]2=[CH:3][CH:4]=1)=[O:10]

Participants

7

Reactant 5

HCID 176Acetic AcidHCID 2631-ButanolHCID 962WaterHCID 6212ChloroformHCID 8471Triethylamine

Product 1

HCID 10236NinhydrinYield 0.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The product gave a single spot with Rf =0.77 and Rf =0.42, respectively by silica gel thin layer chromatography (Developing solvent, n-butanol:acetic acid:water=4:2:2; and chloroform:methanol:triethylamine=40:2:1, Colour forming method: spraying of 0.1% ninhydrine, and heating).

Workup

  1. customThe product gave a single spot with Rf =0.77 and Rf =0.42

Sources & evidence

ORD record
ord-69bd829adf614352b0175fb3376ad368
Source dataset
uspto-grants-1984_09
Patent number
US04472381

Reaction notes

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