HRID2418603

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CSCC[C@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(N)=O

HCID131713792

未命名化合物

PRODUCTS

生成物

结构：CSCC[C@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](N)Cc1c[nH]c2ccccc12)C(N)=O

HCID131713791

未命名化合物

收率 74%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1068

Dimethyl sulfide

C2H6S

溶剂HCID33645

Ethane-1,1-dithiol

C2H6S2

PROCEDURE

实验过程

Condensation of BocMeLeuOH (5.0 g.) and HMetNH2 (3.7 g.) by the mixed anhydride method using diphenylphosphinyl chloride gave BocMeLeu-MetNH2 in 67% yield. De-t-butoxycarbonylation of BocMeLeu-MetNH2 (5.2 g.) using hydrogen chloride in ethyl acetate gave HMeLeu-MetNH2 in 90% yield. Condensation of BocDTrpOPFP (5.60 g.) and HMeLeu-MetHN2 (3.70 g.) by the activated ester method gave BocDTrp-MeLeu-MetNH2 in 55% yield. De-t-butoxycarbonylation of BocDTrp-MeLeu-MetNH2 (3.38 g.) using trifluoroacetic acid in dimethyl sulfide and ethanedithiol gave HDTrp-MeLeu-MetNH2 in 74% yield.