Benzyl Isothiocyanate → HCID 13339828, compound

HRID 2418639Notes

Reaction equation

HRID 2418639 reaction equation
[C:1]1([NH:7][CH2:8][C:9]([OH:11])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:12]([N:19]=[C:20]=[S:21])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C1(C)C=CC=CC=1>[C:1]1([N:7]2[CH2:8][C:9](=[O:11])[N:19]([CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:20]2=[S:21])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 2346Benzyl IsothiocyanateHCID 66025N-Phenylglycine

Product 1

HCID 13339828HCID 13339828, compoundYield 20%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture containing 30.2 g (0.2 M) of N-phenyl glycine, 37.2 g (0.25M) of benzylisothiocyanate and 80 ml of toluene was refluxed for 5 hours and allowed to stand at room temperature overnight. The product was washed with toluene and recrystallized from ethanol to produce 12 g (0.04 mole) of the above-identified product having a melting point of 103° C.

Workup

  1. temperaturewas refluxed for 5 hours
  2. washThe product was washed with toluene
  3. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-a5cf3dc600724936863c9aa43582757c
Source dataset
uspto-grants-1984_09
Patent number
US04473393

Reaction notes

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