Oxalyl chloride → HCID 20444701, compound

HRID 2418646Notes

Reaction equation

HRID 2418646 reaction equation
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:15]=[C:16](C(O)=O)[C:17](C)=[N:18][CH:19]=2)=[CH:10][CH:9]=1>C(Cl)Cl>[ClH:4].[Cl:7][C:8]1[CH:9]=[CH:10][C:11]([C:14]2[CH:15]=[C:1]([C:2]([Cl:4])=[O:3])[C:17]([CH3:16])=[N:18][CH:19]=2)=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 13079828HCID 13079828, compound

Product 1

HCID 20444701HCID 20444701, compoundYield 97.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Oxalyl chloride (11.52 gms) in dry methylene dichloride (10 ml) was slowly added to a suspension of 5-(p-chlorophenyl)-2-methyl-3-pyridine carboxylic acid (10 g) in dry methylene dichloride (50 ml). After standing for 1 hour at room temperature, the mixture was concentrated and the residue washed with dry diethyl ether, collected and dried to give 5-(p-chlorophenyl)-2-methyl-3-chlorocarbonylpyridine hydrochloride (11.95 g).

Workup

  1. concentrationthe mixture was concentrated
  2. washthe residue washed with dry diethyl ether
  3. customcollected
  4. customdried

Sources & evidence

ORD record
ord-11ed6346027f4fa4b580ba0c507d2277
Source dataset
uspto-grants-1984_09
Patent number
US04473395

Reaction notes

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