Hydrochloric Acid → HCID 70496392, compound

HRID 2418679Notes

Reaction equation

HRID 2418679 reaction equation
CS[C:3]1[N:8]2[C:9]([CH3:12])=[N:10][CH:11]=[C:7]2[CH:6]=[C:5]([S:13][CH3:14])[N:4]=1.C[O-].[Na+].Cl.C(=O)(O)[O-:20].[Na+]>O.CO>[CH3:12][CH:9]1[N:8]2[C:3](=[O:20])[N:4]=[C:5]([S:13][CH3:14])[CH:6]=[C:7]2[CH:11]=[N:10]1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 10942334Sodium MethoxideHCID 13339915HCID 13339915, compound

Product 1

HCID 70496392HCID 70496392, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 962WaterSolvent

Procedure

To a solution of 4.8 g (21.3 mmole) of 5,7-bis(methylthio)-3-methylimidazo[1,5-c]pyrimidine in 10 ml of water and 90 ml of methanol was added 5.0 g (23.1 mmole) of 25% sodium methoxide in methanol. The mixture was heated at reflux for 16 hours, poured into 400 ml of an ice-water mixture, and acidified with 3 ml of concentrated hydrochloric acid. The mixture was basified with solid sodium bicarbonate, and the precipitate was separated by filtration. The solid was washed with water and dried to provide 3-methyl-7-methylthioimidazo[1,5-c]pyrimidin-5-one, m.p. 221°-222° C. Analysis: Calculated for C8H9N3OS; %C, 49.2; %H, 4.7; %N, 21.5; Found; %C, 48.9; %H, 4.6; %N, 21.6.

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 16 hours
  3. customthe precipitate was separated by filtration
  4. washThe solid was washed with water
  5. customdried

Sources & evidence

ORD record
ord-13e56f22f51c483fb8cf83b87a249f04
Source dataset
uspto-grants-1984_09
Patent number
US04473570

Reaction notes

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