Hydrochloric Acid → HCID 58103573, compound

HRID 241869Notes

Reaction equation

HRID 241869 reaction equation
[CH:1]1([C@H:4]([C:12]2[CH:13]=[N:14][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:16][CH:17]=2)[NH:5][S@@](C(C)(C)C)=O)[CH2:3][CH2:2]1.C(O)C.Cl>O1CCOCC1>[CH:1]1([C@H:4]([C:12]2[CH:13]=[N:14][C:15]([C:18]([F:21])([F:19])[F:20])=[CH:16][CH:17]=2)[NH2:5])[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 66872457HCID 66872457, compound

Product 1

HCID 58103573HCID 58103573, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(R)-N-((R)-Cyclopropyl(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-methylpropane-2-sulfinamide (0.245 g, 0.765 mmol), ethanol (2.7 mL), and 4.0 M of hydrogen chloride in dioxane (2.7 mL) were combined and the mixture was stirred at rt overnight. Reaction was concentrated down to an oil and then redissolved and washed with ethanol 3 times, and concentrated. The residue was dried on the high vacuum overnight to obtain a white solid.

Workup

  1. customReaction
  2. concentrationwas concentrated down to an oil
  3. dissolutionredissolved
  4. washwashed with ethanol 3 times
  5. concentrationconcentrated
  6. customThe residue was dried on the high vacuum overnight
  7. customto obtain a white solid

Sources & evidence

ORD record
ord-6e7c17e630bf4a9aa98c86325b4d592f
Source dataset
uspto-grants-2014_02
Patent number
US08653091B2

Reaction notes

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