Hydrochloric Acid → HCID 58103591, compound

HRID 241870Notes

Reaction equation

HRID 241870 reaction equation
[CH:1]1([C@H:4]([C:12]2[CH:13]=[N:14][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:16][CH:17]=2)[NH:5][S@](C(C)(C)C)=O)[CH2:3][CH2:2]1.C(O)C.Cl.O1CCOCC1>>[CH:1]1([C@@H:4]([C:12]2[CH:13]=[N:14][C:15]([C:18]([F:21])([F:19])[F:20])=[CH:16][CH:17]=2)[NH2:5])[CH2:3][CH2:2]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 312751,4-DioxaneHCID 66871736HCID 66871736, compound

Product 1

HCID 58103591HCID 58103591, compound

Procedure

(S)-N-((R)-cyclopropyl(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-methylpropane-2-sulfinamide (0.245 g, 0.000765 mol), Ethanol (2.7 g, 0.059 mol), and 4.0 M of Hydrogen chloride in Dioxane (2.7 mL, 0.011 mol) are combined and stirred for 30 minutes. The mixture is allowed to stir overnight. The solvent is removed and the residue is dissolved in ethanol. After washing with ethanol 3 more times, the mixture is concentrated and the residue is dried under high vacuum overnight to obtain a solid.

Workup

  1. stirringto stir overnight
  2. customThe solvent is removed
  3. dissolutionthe residue is dissolved in ethanol
  4. washAfter washing with ethanol 3 more times
  5. concentrationthe mixture is concentrated
  6. customthe residue is dried under high vacuum overnight
  7. customto obtain a solid

Sources & evidence

ORD record
ord-5c7397b2f2ac41068b821caaae9b5f6d
Source dataset
uspto-grants-2014_02
Patent number
US08653091B2

Reaction notes

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