Cyclohexanone → 3-(Difluoromethyl)cyclohexan-1-one

HRID 2418855Notes

Reaction equation

HRID 2418855 reaction equation
O=C1CCCCC1.O=S(O)C(F)F.[Zn]>CC(C)(C)OO.ClCCl.O.O=C(O)C(F)(F)F>O=C1CCCC(C(F)F)C1

Participants

7

Reactant 2

HCID 7967CyclohexanoneHCID 89600919CID 89600919

Product 1

HCID 847163613-(Difluoromethyl)cyclohexan-1-oneYield 40%

Reagents, catalysts & solvents 4

HCID 6410tert-Butyl hydroperoxideReagentHCID 6422Trifluoroacetic acidReagentHCID 962WaterSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-d51500b03fe841a88e9a1159a0bbb3ff
Source dataset
Minisci dataset from Roche

Reaction notes

Loading…