Methyl 5-methoxypyridine-3-carboxylate → HCID 89601073, compound

HRID 2418867Notes

Reaction equation

HRID 2418867 reaction equation
COC(=O)c1cncc(OC)c1.O=S(O)C(F)F.[Zn]>CC(C)(C)OO.ClCCl.O.O=C(O)C(F)(F)F>COC(=O)c1cc(OC)cnc1C(F)F.COC(=O)c1cnc(C(F)F)c(OC)c1.COC(=O)c1cncc(OC)c1C(F)F

Participants

9

Reactant 2

HCID 16218325Methyl 5-methoxypyridine-3-carboxylateHCID 89600919CID 89600919

Product 3

HCID 896008893-Pyridinecarboxylic acid, 6-(difluoromethyl)-5-methoxy-, methyl esterYield 20%HCID 89600998HCID 89600998, compoundYield 20%HCID 89601073HCID 89601073, compoundYield 40%

Reagents, catalysts & solvents 4

HCID 6410tert-Butyl hydroperoxideReagentHCID 6422Trifluoroacetic acidReagentHCID 962WaterSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-46ec5ff5d8a0412a95b56b4da9ce56fd
Source dataset
Minisci dataset from Roche

Reaction notes

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