2-Cyanopyrimidine → 5-Isopropylpyrimidine-2-carbonitrile

HRID 2418894Notes

Reaction equation

HRID 2418894 reaction equation
CC(C)S(=O)O.N#Cc1ncccn1.[Zn]>CC(C)(C)OO.CS(C)=O.O>CC(C)c1ccnc(C#N)n1.CC(C)c1cnc(C#N)nc1

Participants

7

Reactant 2

HCID 27579792-CyanopyrimidineHCID 117778686Propane-2-sulfinic acid;ZINC

Product 2

HCID 680772155-Isopropylpyrimidine-2-carbonitrileYield 31%HCID 1169007894-Isopropylpyrimidine-2-carbonitrileYield 15%

Reagents, catalysts & solvents 3

HCID 6410tert-Butyl hydroperoxideReagentHCID 679Dimethyl SulfoxideSolventHCID 962WaterSolvent

Conditions

Temperature
50 °C

Sources & evidence

ORD record
ord-5a26c173c5de493690cc1c0af2653970
Source dataset
Minisci dataset from Roche

Reaction notes

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