Ethyl isonicotinate → Ethyl 2-(trifluoromethyl)pyridine-4-carboxylate

HRID 2418905Notes

Reaction equation

HRID 2418905 reaction equation
CCOC(=O)c1ccncc1.O=S(O)C(F)(F)F.[Zn]>CC(C)(C)OO.ClCCl.O>CCOC(=O)c1ccnc(C(F)(F)F)c1

Participants

6

Reactant 2

HCID 15291Ethyl isonicotinateHCID 89601280CID 89601280

Product 1

HCID 46311440Ethyl 2-(trifluoromethyl)pyridine-4-carboxylateYield 7%

Reagents, catalysts & solvents 3

HCID 6410tert-Butyl hydroperoxideReagentHCID 962WaterSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-d16d8f108c9f42eca8fbd6eaffe96107
Source dataset
Minisci dataset from Roche

Reaction notes

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