4-Pyridineacetic acid hydrochloride → 2-(Trifluoromethyl)-4-pyridineacetic acid

HRID 2418911Notes

Reaction equation

HRID 2418911 reaction equation
Cl.O=C(O)Cc1ccncc1.O=S(O)C(F)(F)F.[Zn]>CC(C)(C)OO.ClCCl.O>O=C(O)Cc1ccnc(C(F)(F)F)c1

Participants

6

Reactant 2

HCID 810974-Pyridineacetic acid hydrochlorideHCID 89601280CID 89601280

Product 1

HCID 711233682-(Trifluoromethyl)-4-pyridineacetic acidYield 57%

Reagents, catalysts & solvents 3

HCID 6410tert-Butyl hydroperoxideReagentHCID 962WaterSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-316b8ce895954fe5a7b1712c65a9a0f2
Source dataset
Minisci dataset from Roche

Reaction notes

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