Sodium ethoxide → Butan-1-olate

HRID 2419035Notes

Reaction equation

C[O-].[Na+:3].[O-:4][CH2:5][CH3:6].[Na+].[CH3:8][CH:9]([CH3:11])[O-:10].[Na+].[Na]>>[O-:4][CH2:5][CH2:6][CH2:8][CH3:9].[CH3:8][C:9]([CH3:5])([O-:10])[CH3:11].[Na+:3]

Participants

Reactant 4

HCID 2723922Sodium ethoxide

HCID 5360545Sodium

HCID 109204432-Propanol, sodium salt (1:1)

HCID 10942334Sodium Methoxide

Product 2

HCID 12476378Butan-1-olate

HCID 23676156Sodium t-butoxide

Procedure

Employing the procedure substantially as described in Example 1, Step E, but substituting for the sodium methoxide used therein, an equimolecular amount of sodium ethoxide, sodium n-propoxide, sodium isopropoxide, sodium n-butoxide, sodium sec.-butoxide, or sodium t-butoxide, there is produced respectively (-)-3-ethoxycyproheptadine, (-)-3-n-propoxycyproheptadine, (-)-3-isopropoxycyproheptadine, (-)-3-n-butoxycyproheptadine, (-)-3-sec.-butoxycyproheptadine, or (-)-3-t-butoxycyproheptadine.

Sources & evidence

ORD record: ord-926f4bea06d94334a997954637593028
Source dataset: uspto-grants-1978_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04104398

Reaction notes

Loading…