Formicin → 3-Acetamidomethylthio-2-methylpropanoic acid

HRID 2419451Notes

Reaction equation

HRID 2419451 reaction equation
[SH:1][CH2:2][CH:3]([CH3:7])[C:4]([OH:6])=[O:5].O[CH2:9][NH:10][C:11](=[O:13])[CH3:12]>FC(F)(F)C(O)=O>[C:11]([NH:10][CH2:9][S:1][CH2:2][CH:3]([CH3:7])[C:4]([OH:6])=[O:5])(=[O:13])[CH3:12]

Participants

4

Reactant 2

HCID 69365FormicinHCID 1529103-Mercaptoisobutyric acid

Product 1

HCID 213191453-Acetamidomethylthio-2-methylpropanoic acid

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

3-Mercapto-2-methylpropanoic acid (2.4 g.) and N-hydroxymethylacetamide (1.8 g.) are dissolved in trifluoroacetic acid and the solution is stored at room temperature for 1 hour. The trifluoroacetic acid is removed in vacuo and the residue is dried in vacuo over potassium hydroxide to yield 3-acetamidomethylthio-2-methylpropanoic acid.

Workup

  1. customThe trifluoroacetic acid is removed in vacuo
  2. dry with materialthe residue is dried in vacuo over potassium hydroxide

Sources & evidence

ORD record
ord-9ce6ca10b0564db095d2593f683b4cff
Source dataset
uspto-grants-1978_08
Patent number
US04105776

Reaction notes

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