反应详情

A suspension of H-Lys(Z)-OH (0.89 g, 3.18 mmol) in DMF (25 ml) was stirred with Et3N (0.5 ml) and Boc-Glu(OBzl)-OSu (1.58 g, 3.5 mmol) at 0° C for 1 hr and 25° C for 24 hr. The reaction mixture was worked up as described above in Example 2 to produce a clear oil which was crystallized from EtOAc and petroleum ether to yield 1.47 g (77.4%); mp 110°-112° C.; [α]D25 +6.0° (c 1, CHCl3). Anal. Calcd for C31H41N3O9 (599.69): C, 62.08; H, 6.89; N, 7.00. Found: C, 62.04; H, 6.96; N, 7.10.

1. customto produce a clear oil which
2. customwas crystallized from EtOAc and petroleum ether
3. customto yield 1.47 g (77.4%)