反应详情

温度

220 °C

Phenylisothiocyanate (8.8g) and 5-chloro-1,2,3-benzothiadiazole (3.75g) are combined under an inert atmosphere and heated at 220° C until nitrogen evolution ceases. Initial purification of the product is accomplished by dry column chromatography (600g alumina column, benzene solvent). The product is further purified with a methylene chloride wash and recrystallization (twice) from pentane to yield 1.5g of the title compound, melting point 71°-73° C.

1. customInitial purification of the product
2. dry with materialby dry column chromatography (600g alumina column, benzene solvent)
3. customThe product is further purified with a methylene chloride
4. washwash
5. customrecrystallization (twice) from pentane