Methyl iodide → HCID 13548774, compound

HRID 2419662Notes

Reaction equation

HRID 2419662 reaction equation
[Na].[CH3:2][C:3]1[N:7]2[C:8](=[S:12])[NH:9][N:10]=[CH:11][C:6]2=[CH:5][N:4]=1.[CH3:13]I>CO>[CH3:2][C:3]1[N:7]2[C:8]([S:12][CH3:13])=[N:9][N:10]=[CH:11][C:6]2=[CH:5][N:4]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 5360545SodiumHCID 13548756HCID 13548756, compound

Product 1

HCID 13548774HCID 13548774, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 0.23 gm. of sodium in 10 ml. of methanol is added 1.66 gm. of 6-methyl-imidazo[1,5-d]-as-triazine-4(3H)-thione with warming to produce a solution. The mixture is cooled to room temperature and 0.75 ml. of methyl iodide is added. Cooling overnight gives a solid which is recrystallized from a mixture of 20 ml. of acetone and 6 ml. of ethanol and treated with charcoal. This solid is recrystallized from 20 ml. of ethanol, giving the desired product, m.p. 182.5°-184° C.

Workup

  1. customto produce a solution
  2. temperatureCooling overnight
  3. customgives a solid which
  4. customis recrystallized from a mixture of 20 ml
  5. additionof ethanol and treated with charcoal
  6. customThis solid is recrystallized from 20 ml

Sources & evidence

ORD record
ord-52508b4a52854f5facbc4aebabaf5b8d
Source dataset
uspto-grants-1978_08
Patent number
US04107308

Reaction notes

Loading…